Press Release Summary: This week AnaSpec, a world leader in custom and catalog peptides, introduced eleven (11) new peptides.
Press Release Body: June 16, 2008 - San Jose, CA
This week AnaSpec, a world leader in custom and catalog peptides, introduced eleven (11) new peptides.
[dAla2,Cys4]Deltorphin C- Cat# 62680 This deltorphin C (or deltorphin 1) peptide modification is a selective agonist at the supraspinal opioid delta-1 receptor subtype in mouse. It was evaluated in an anti-nociceptive assay after i.c.v. administration to mice. It was shown to produce dose-related anti-nociceptive effects. Sequence: YaFCVVG-NH2
Deltorphin A- Cat# 62682 Deltorphin A peptide was isolated from skin extracts of the South American frog, Phyllomedusa sauvagei. Deltorphin A is a potent and selective agonist for the delta-opioid receptor. Sequence: YmFHLMD-NH2
CMV EP 88, Cytomegalovirus Early Protein pp89 Derivative, YPHFMPTNL,- Cat# 62781 This peptide is processed from the immediate early protein pp89 of mouse cytomegalovirus (CMV). It is presented to CD8+ T lymphocytes by the H-2 Ld molecule. Infection of mice with murine CMV leads to CD8 cell responses to this immunodominant epitope. This peptide was employed in vaccines development. Sequence: YPHFMPTNL
CHK1tide, 5-TAMRA labeled- Cat# 62807-1 This is checkpoint kinase CHK1 substrate labeled with TAMRA. CHK1 is an evolutionarily conserved protein kinase that has been implicated in cell cycle checkpoint control in lower eukaryotes. Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression. Sequence: TAMRA-ALKLVRYPSFVITAK-NH2
CHK1tide, 5-TAMRA labeled- Cat# 62807-5 This is checkpoint kinase CHK1 substrate labeled with TAMRA. CHK1 is an evolutionarily conserved protein kinase that has been implicated in cell cycle checkpoint control in lower eukaryotes. Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression. Sequence: TAMRA-ALKLVRYPSFVITAK-NH2
CHK1tide, FAM labeled- Cat# 62806-1 This is checkpoint kinase CHK1 substrate labeled with 5-FAM. CHK1 is an evolutionarily conserved protein kinase that has been implicated in cell cycle checkpoint control in lower eukaryotes. Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression. Sequence: FAM-ALKLVRYPSFVITAK-NH2
CHK1tide, FAM labeled- Cat# 62806-5 This is checkpoint kinase CHK1 substrate labeled with 5-FAM. CHK1 is an evolutionarily conserved protein kinase that has been implicated in cell cycle checkpoint control in lower eukaryotes. Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppression. Sequence: FAM-ALKLVRYPSFVITAK-NH2
Neurotensin- Cat# 62677 This 13 amino acid peptide was first isolated from bovine hypothalamus and was named from its neuronal localization. It was detected in the central nervous system (CNS) and peripheral tissues mainly in the gastrointestinal tract. This bioactive form of neurotensin post-translationally modified at a Glu residue was isolated from porcine intestine. In the CNS, neurotensin has dual function of neuromodulator of dopamine transmission and of anterior pituitary hormone secretion. It also shows potent hypothermic and analgesic effects in the brain. Neurotensin has been implicated in the pathophysiology of schizophrenia, Huntington, and Parkinson diseases. Sequence: QLYENKPRRPYIL
Leucokinin II, Myokinin II, Anopheles- Cat# 62768 This peptide belongs to the Anopheles leucokinin II. Insect leucokinins elicit potent diuretic effects on the Malpighian tubules of insects, and contraction of the hindgut hence the alternative term "myokinin." This is the shortest of all three Anopheles leucokinins, with the sequence identical to culekinin I, and Aedes leucokinin II. Sequence: NPFHSWG-NH2
MAGE-3 (114-127)- Cat# 62702 This is amino acids 114 to 127 fragment of the MAGE-3 protein. Among the MAGE genes, MAGE-3 is one of the most frequently expressed in tumors. For instance, it is expressed in 76% of metastatic melanomas. This peptide binds to HLA molecules and hence could be a target antigen for an antitumor CTL response. Sequence: AELVHFLLLKYRAR
MAGE-3 (121-134)- Cat# 62701 This is amino acids 121 to 134 fragment of the MAGE-3 protein. MAGE-type genes are expressed by many tumors of different histological types and not by normal cells, except for male germline cells. Therefore, the antigens encoded by MAGE-type genes are strictly tumor specific and common to many tumors. This peptide is presented by the HLA-DR13 molecule which is expressed in 20% of XCaucasians. Sequence: LLKYRAREPVTKAE
Company Info AnaSpec, Inc. is a leading provider of integrated proteomics solutions to pharmaceutical, biotech, and academic research institutions throughout the world. With a vision for innovation through synergy, AnaSpec focuses on three core technologies: peptides, detection reagents, and combinatorial chemistry. Established in 1993, AnaSpec\'s headquarters and manufacturing facilities are located in San Jose, CA.
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